F-fluorodeoxyglucose-positron emission tomography findings are not related to cognitive functioning in service members with remote history of mild traumatic brain injury

Determine whether glucose uptake as measured by 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging is associated with cognitive performance and cognitive deficits in active duty service members with a history of mild traumatic brain injury (mTBI). 287 patients with a history of mT...

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Bibliographic Details
Published in:Neuropsychology 2023-01, Vol.37 (1), p.20-31
Main Authors: Lippa, Sara M, Song, Chihwa, Bonavia, Grant H, Oakes, Terrence R, Ollinger, John
Format: Article
Language:English
Subjects:
Brain
Brain Concussion
Brain Concussion - complications
Brain Concussion - diagnostic imaging
Cognition
Cognitive Ability
Deoxyglucose
Female
Fluorodeoxyglucose F18
Glucose
Human
Humans
Male
Military Personnel
Neuroimaging
Patient History
Positron Emission Tomography
Positron-Emission Tomography - methods
Tomography
Traumatic Brain Injury
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Summary:Determine whether glucose uptake as measured by 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging is associated with cognitive performance and cognitive deficits in active duty service members with a history of mild traumatic brain injury (mTBI). 287 patients with a history of mTBI underwent FDG-PET scans at rest and neuropsychological testing at the National Intrepid Center of Excellence at Walter Reed National Military Medical Center. Glucose uptake in the bilateral frontal, parietal, occipital, and temporal lobes, and 58 cortical/cerebellar regions were correlated with seven neuropsychological composite scores, with and without relevant covariates. Perceptual reasoning correlated with bilateral hippocampi glucose uptake ( s = .141-.165, < .03), processing speed was inversely related to glucose uptake in the left temporal lobe ( = -.134, = .034), and working memory was related to glucose uptake in the left parietal, temporal, and occipital lobes ( s = .128-.140, < .05); however, these findings did not survive correction for multiple comparisons. Partial correlations between cognition and the 56 cortical/cerebellar regions of interests were not significant after correction for multiple comparisons. Glucose uptake in the left hippocampus was inversely related to the likelihood of cognitive deficits ( = .745, = .041); however, this did not survive correction for multiple comparisons. After correction for multiple comparisons, there was no significant relationship between regional glucose uptake and neurocognitive performance or cognitive deficits. Glucose uptake as measured by FDG-PET is not indicative of cognitive performance in active duty service members with a remote history of mTBI. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
ISSN:0894-4105
1931-1559
1931-1559
DOI:10.1037/neu0000861