Are there differences in outcomes by race among women with metastatic triple-negative breast cancer?

Purpose Black women have higher breast cancer mortality rates than other groups, with Triple-negative breast cancer (TNBC) being more common among AAs with a worse prognosis. Our study seeks to explore differences among Non-Hispanic Black (NHB) vs. White (NHW) women, with Stage IV TNBC, focusing on...

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Bibliographic Details
Published in:Breast cancer research and treatment 2022-11, Vol.196 (2), p.399-408
Main Authors: Oppong, Bridget A., Rolle, Angel A., Ndumele, Amara, Li, Yaming, Fisher, James L., Bhattacharyya, Oindrila, Adeyanju, Toyin, Paskett, Electra D.
Format: Article
Language:English
Subjects:
Analysis
Breast cancer
Cancer
Cancer research
Cancer therapies
Care and treatment
Chemotherapy
Epidemiology
Health aspects
Medical prognosis
Medicine
Medicine & Public Health
Metastases
Metastasis
Mortality
Multivariate analysis
Oncology
Oncology, Experimental
Patients
Prognosis
Radiation
Surgery
Survival
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Summary:Purpose Black women have higher breast cancer mortality rates than other groups, with Triple-negative breast cancer (TNBC) being more common among AAs with a worse prognosis. Our study seeks to explore differences among Non-Hispanic Black (NHB) vs. White (NHW) women, with Stage IV TNBC, focusing on survival and treatment patterns. Methods SEER database was queried for TNBC patients diagnosed with metastatic disease from 2012 to 2016. Neighborhood socioeconomic status (nSES) was defined using the Yost index based on income, education, housing, and employment. Univariate and multivariate analyses were performed to evaluate receipt of surgery, radiation, and chemotherapy. Overall survival was evaluated using Kaplan–Meier curve and Cox proportional hazards model analysis. Results 25,761 TNBC cases were identified with 1420 being metastatic (5.5%). Bone was the most common site for metastasis, with patients’ age being 63.7 years for NHW vs. 59.5 years for NHB. NHB women had the highest percentage of low nSES (62.3% vs 29.3%; p value = 0.001). On univariate analysis, fewer NHBs received radiation compared to NHWs (27.1 vs. 32.6%; p value = 0.040). On multivariate analysis, all women were less likely to undergo treatment if unmarried ( p value 
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-022-06736-8