Role of DNA damage in the pathogenesis of atherosclerosis

Atherosclerosis is a cause of coronary artery disease, abdominal aortic aneurysm, and stroke. The pathogenesis underlying atherosclerosis is complex but it is clear that inflammation plays a pivotal role. Inflammation in atherosclerosis is triggered by the recognition of intracellular contents relea...

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Bibliographic Details
Published in:Journal of cardiology 2023-04, Vol.81 (4), p.331-336
Main Authors: Ishida, Mari, Sakai, Chiemi, Ishida, Takafumi
Format: Article
Language:English
Subjects:
Atherosclerosis
Atherosclerosis - genetics
Cellular Senescence
Coronary Artery Disease - complications
Cytosolic DNA
DNA Damage
Humans
Inflammation
Inflammation - complications
Senescence
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Summary:Atherosclerosis is a cause of coronary artery disease, abdominal aortic aneurysm, and stroke. The pathogenesis underlying atherosclerosis is complex but it is clear that inflammation plays a pivotal role. Inflammation in atherosclerosis is triggered by the recognition of intracellular contents released from damaged cells by pattern recognition receptors, and is therefore sterile and chronic. Because the DNA of these cells is damaged, cellular senescence is also involved in this inflammation. Here, we will discuss the emerging evidence of a relationship between DNA damage and inflammation in the pathogenesis of atherosclerosis, with a focus on intracellular events and cell fates that arise following DNA damage. Recent evidence will lead us to potential therapeutic targets and allow us to explore potential preventative and therapeutic strategies. [Display omitted] •Accumulating evidence indicates that genomic instability triggers inflammation.•Cellular senescence is involved in the mechanisms of inflammation through senescence-associated secretory phenotype.•Not only the microbial DNA but also the fragmented self-DNA in the cytosol can trigger inflammation.•Recognition of fragmented DNA in the cytosol by DNA sensors induces intracellular processes that lead to inflammation.
ISSN:0914-5087
1876-4738
DOI:10.1016/j.jjcc.2022.08.010