Design and Investigation of an Eco‐Friendly Wound Dressing Composed of Green Bioresources‐ Soy Protein, Tapioca Starch, and Gellan Gum

In the fields of biomedicine and tissue engineering, natural polymer‐based tissue‐engineered scaffolds are used in multiple applications. As a plant‐derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra‐cellular matrix (ECM) of tissues. It...

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Bibliographic Details
Published in:Macromolecular bioscience 2022-12, Vol.22 (12), p.e2200288-n/a
Main Authors: Lin, Che‐Wei, Wu, Po‐Ting, Chuang, Er‐Yuan, Fan, Yu‐Jui, Yu, Jiashing
Format: Article
Language:English
Subjects:
Amino acids
Bandages
Cell migration
Cell proliferation
Cellular structure
Chemical composition
composite scaffold
Computed tomography
Cytology
Extracellular matrix
Fibroblasts
Functional groups
Gellan gum
Granulation
Manihot
Mechanical properties
Natural polymers
Polymers
Polymers - chemistry
Polysaccharides
Proteins
Saccharides
Scaffolds
Scanning electron microscopy
skin wound healing model
soy protein
Soybean Proteins - chemistry
Soybean Proteins - pharmacology
Starch
Starch - pharmacology
Tapioca
Tissue engineering
Tissue Engineering - methods
Tissue Scaffolds - chemistry
Wound healing
X-Ray Microtomography
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Summary:In the fields of biomedicine and tissue engineering, natural polymer‐based tissue‐engineered scaffolds are used in multiple applications. As a plant‐derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra‐cellular matrix (ECM) of tissues. It is biological safety provided a good potential to be material for pure natural scaffolds. Moreover, as a protein, the properties of soy protein can be easily adjusted by modifying the functional groups on it. In addition, by blending soy protein with other synthetic and natural polymers, the mechanical characteristics and bioactive behavior of scaffolds can be facilitated for a variety of bio‐applications. In this research, soy protein and polysaccharides tapioca starch are used, and gellan gum to develop a protein‐based composite scaffold for cell engineering. The morphology and surface chemical composition are characterized via micro‐computed tomography (micro‐CT), scanning electron microscope (SEM), and fourier‐transform infrared (FTIR) spectroscopy. The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold. In addition, STG composite scaffolds show great potential in the wound healing model to enhance rapid epithelialization and tissue granulation. Green and renewable, plant proteins and polysaccharides have inherent nontoxicity, good biocompatibility, biodegradability, and environmental friendliness; when reinforced with gellan gum water‐soluble anionic polysaccharide and cross‐linked with divalent cations, the synthesized scaffold shows promising advantages as a wound dressing candidate.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.202200288