Genetic Variations in Elements of the Oxytocinergic Pathway are Associated with Attention/Hyperactivity Problems and Anxiety Problems in Childhood

Genetic alterations related to oxytocin system seem to influence the neurobiology of attention-deficit hyperactivity disorder and anxiety problems leading to greater functional, social and emotional impairment. Here, we analyzed the association of OXTR rs2254298 and CD38 rs6449182 variants with atte...

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Published in:Child psychiatry and human development 2024-04, Vol.55 (2), p.552-563
Main Authors: Camerini, Laísa, Zurchimitten, Gabriel, Bock, Bertha, Xavier, Janaína, Bastos, Clarissa Ribeiro, Martins, Evânia, Ardais, Ana Paula, dos Santos Motta, Janaína Vieira, Pires, Andressa Jacondino, de Matos, Mariana Bonati, de Ávila Quevedo, Luciana, Pinheiro, Ricardo Tavares, Ghisleni, Gabriele
Format: Article
Language:English
Subjects:
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Anxiety
Anxiety - genetics
Attention Deficit Disorder with Hyperactivity - genetics
Attention Deficit Disorder with Hyperactivity - psychology
Attention deficit hyperactivity disorder
Autism
Behavior disorders
Behavioral Science and Psychology
Brain research
CD38 antigen
Child
Child & adolescent psychiatry
Child and School Psychology
Child psychology
Childhood
Children
Children & youth
Chromatin
Cohort analysis
Emotions
Genetic diversity
Genetic Variation - genetics
Genotypes
Hormones
Humans
Hyperactivity
Neurobiology
Neurosciences
Original Article
Oxytocin
Oxytocin - genetics
Oxytocin - metabolism
Polymorphism
Psychiatry
Psychology
Receptors, Oxytocin - genetics
Risk factors
Teenagers
Urban areas
Variants
Womens health
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Summary:Genetic alterations related to oxytocin system seem to influence the neurobiology of attention-deficit hyperactivity disorder and anxiety problems leading to greater functional, social and emotional impairment. Here, we analyzed the association of OXTR rs2254298 and CD38 rs6449182 variants with attention/hyperactivity problems and anxiety problems in children. The study enrolled 292 children and adjusted regression model revealed OXTR rs2254298 AA genotype as a risk factor for attention deficit/hyperactivity problems (PR: 2.37; P adjFDR = 0.006), attention problems (PR: 2.71; P adjFDR = 0.003) and anxiety problems (PR: 1.92; P adjFDR = 0.018). CD38 rs6449182 G allele showed as a risk factor for attention deficit/hyperactivity problems (PR: 1.56; P adjFDR = 0.028). Moreover, in silico approach for regulatory roles found markers that influence chromatin accessibility and transcription capacity. Together, these data provide genetic information of oxytocin in developmental and behavioral disorders opening a range of opportunities for future studies that clarify their neurobiology in childhood.
ISSN:0009-398X
1573-3327
DOI:10.1007/s10578-022-01419-3