Impact of Embryo Cryopreservation on Large for Gestational Age Babies Born by Embryo Transfer: Cohort Retrospective Study

The transfer of frozen-thawed embryos has been associated with an increased risk of large for gestational age at birth. Our objective is to assess its impact on the risk of large for gestational age (LGA) in order to improve the bias control in relation with the available studies. Retrospective coho...

Full description

Saved in:
Bibliographic Details
Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2023-04, Vol.30 (4), p.1257-1265
Main Authors: Trobo, Duna, García, Cecilia, Martínez, Marta, Rodríguez, Inés, Rojo, María, Moreno, Sonsoles, Nozaleda, Gonzalo, Solís, Ana, Pérez, Laura, Caballero, Miguel, Ceballos, Elena, Navarro, María T., Pérez-Milán, Federico Mariano
Format: Article
Language:English
Subjects:
Birth Weight
Cohort Studies
Cryopreservation - methods
Embryo Transfer - adverse effects
Embryo Transfer - methods
Embryology
Female
Fertilization in Vitro - methods
Gestational Age
Humans
Infant
Infant, Newborn
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Pregnancy
Reproductive Biology: Original Article
Reproductive Medicine
Retrospective Studies
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The transfer of frozen-thawed embryos has been associated with an increased risk of large for gestational age at birth. Our objective is to assess its impact on the risk of large for gestational age (LGA) in order to improve the bias control in relation with the available studies. Retrospective cohort study on cumulative sample of 801 single live births of 32 weeks or longer of gestation, resulting from pregnancies obtained by cryopreserved or fresh embryo transfer which are not affected by disorders that could impair fetal growth and carried out at Hospital General Universitario Gregorio Marañón, in Madrid, during the period 2005–2017. The relative risk (RR) of LGA has been estimated with its confidence interval (CI) at 95%. Multivariate analysis using logistic regression was applied to adjust the crude effect. LGA was more frequent in babies born after cryotransfer in comparison with the reference group (20.9% vs. 6.0%; p   0.05). Nulliparity was associated to a higher risk of LGA (RR: 3.8; CI95%: 2.0–7.0; p  
ISSN:1933-7191
1933-7205
DOI:10.1007/s43032-022-01075-x