Topical application of melatonin accelerates the maturation of skin wounds and increases collagen deposition in a rat model of diabetes

This study aimed to evaluate the cicatricial potential of melatonin when applied to wounds of diabetic rats. The formulation containing melatonin was developed and applied topically to cutaneous wounds of diabetic rats. 48 Wistar rats were used, divided into two groups of 24 diabetic animals each: (...

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Published in:Journal of tissue viability 2022-11, Vol.31 (4), p.606-613
Main Authors: de Souza, Tainara Ribeiro, Rocha, Viviane Lopes, Rincon, Gabriel de Castro Nunes, de Oliveira Junior, Edilson Ribeiro, Celes, Mara Rubia Nunes, Lima, Eliana Martins, Amaral, André Correa, Miguel, Marina Pacheco, de Menezes, Liliana Borges
Format: Article
Language:English
Subjects:
Animals
Chronic wounds
Collagen - pharmacology
Collagen - therapeutic use
Diabetes mellitus
Diabetes Mellitus, Experimental - complications
Diabetes Mellitus, Experimental - drug therapy
Healing
Inflammation
Melatonin - pharmacology
Melatonin - therapeutic use
Rats
Rats, Wistar
Skin
Soft Tissue Injuries
Topical application
Wound Healing
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Summary:This study aimed to evaluate the cicatricial potential of melatonin when applied to wounds of diabetic rats. The formulation containing melatonin was developed and applied topically to cutaneous wounds of diabetic rats. 48 Wistar rats were used, divided into two groups of 24 diabetic animals each: (i) control group (CG), the animals received topical application of the no-melatonin formulation; (ii) treatment group (TG), the animals received topical application of the melatonin-containing formulation. All animals in each group were treated at four time points: 3, 7, 14, and 21 days. Each subgroup consisted of six animals. The treatment with melatonin improved wound healing by promoting wound closure earlier than the control group evaluated. Also improved a better resolution of the inflammatory phase observed mainly at 7 days, higher tissue maturation and expressive collagen deposition. The observed data reveal that the use of melatonin topically could be a promising strategy for the healing of wounds in diabetes. The results of this study elucidate the effects of previously described pathways in which it is proposed that melatonin acts promoting wound healing in diabetes. [Display omitted] •The formulation developed with melatonin increases wound contraction of treated diabetic rats.•Earliest conclusion of inflammation phase of wound healing is observed in Melatonin Treated Group.•Seven days of topical treatment with melatonin induces faster mononuclear recruitment in skin wounds of diabetic Wistar rats.•The formulation containing melatonin increases area of collagen fibers deposition in all time points of treatment observed.
ISSN:0965-206X
DOI:10.1016/j.jtv.2022.07.015