Curcumin as a novel approach in improving lipid profile: An umbrella meta-analysis

Several meta-analyses exist supporting the beneficial effects of curcumin supplementation on lipid profile parameters; however, some studies' findings are inconsistent. Therefore, the current umbrella of meta-analysis of clinical trials was performed to evaluate the findings of multiple meta-an...

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Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2022-11, Vol.32 (11), p.2493-2504
Main Authors: Musazadeh, Vali, Roshanravan, Neda, Mohammadizadeh, Mehdi, Kavyani, Zeynab, Dehghan, Parvin, Mosharkesh, Erfan
Format: Article
Language:English
Subjects:
Cholesterol
Curcumin
Hyperlipidemia
Lipid profile
Meta-analysis
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Summary:Several meta-analyses exist supporting the beneficial effects of curcumin supplementation on lipid profile parameters; however, some studies' findings are inconsistent. Therefore, the current umbrella of meta-analysis of clinical trials was performed to evaluate the findings of multiple meta-analyses on the efficacy of curcumin on lipid profiles in adults. A comprehensive systematic search of PubMed/Medline, Scopus, Embase, Web of Science and Google Scholar were carried out up to May 2022 (in English only). Random-effects model was employed to conduct meta-analysis. The quality assessment of the selected meta-analyses was measured using a measurement tool to assess multiple systematic reviews (AMSTAR). From 101 articles returned in the literature search, 19 articles were met the qualified for inclusion in the umbrella meta-analysis. The results revealed that the curcumin supplementation was effective on reduction of total cholesterol (TC) (ES = −0.81 mg/dl; 95% CI: 1.39, −0.24, p = 0.006; I2 = 68.8%, p 
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2022.07.021