Longitudinal Changes in Smoking Habits in Women and Subsequent Risk of Cancer

This study investigated the association between longitudinal smoking habit changes and cancer risk in a cohort of Korean women. Study population included women aged ≥40 years who underwent 2 biennial cancer screenings (2009–2010 and 2011–2012) and were followed up until 2020. This analysis was condu...

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Bibliographic Details
Published in:American journal of preventive medicine 2022-12, Vol.63 (6), p.894-903
Main Authors: Tran, Thi Xuan Mai, Kim, Soyeoun, Song, Huiyeon, Park, Boyoung
Format: Article
Language:English
Subjects:
Behavior change
Breast cancer
Cancer
Habits
Health risks
Liver
Lung cancer
Medical screening
Nonsmokers
Pancreas
Smoker-Nonsmoker interactions
Smoking
Smoking cessation
Stomach
Women
Womens health
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Summary:This study investigated the association between longitudinal smoking habit changes and cancer risk in a cohort of Korean women. Study population included women aged ≥40 years who underwent 2 biennial cancer screenings (2009–2010 and 2011–2012) and were followed up until 2020. This analysis was conducted in 2021. On the basis of changes in smoking habits, participants were grouped into sustained nonsmokers, sustained quitters, new quitters, relapsers, smoking initiators, and sustained smokers. Outcomes included incident cancer cases, smoking-related cancers, and specific cancer sites. Of 3,051,946 women, the mean age was 54.8 years, and the median follow-up was 8.9 years. Compared with sustained nonsmokers, other groups had a significantly increased risk of cancer and smoking-related cancers: sustained quitters (adjusted hazard ratio=1.05; 95% CI=1.01, 1.09), new quitters (adjusted hazard ratio=1.12; 95% CI=1.07, 1.17), and sustained smokers (adjusted hazard ratio=1.14; 95% CI=1.09, 1.19). A significantly increased risk of lung, stomach, liver, and pancreas cancers was found in sustained smokers and new quitters. Relapsers/smoking initiators showed a higher risk of liver, lung, and breast cancer than sustained nonsmokers, but the strength of their corresponding adjusted hazard ratio was generally lower than that of sustained smokers. The hazard ratio of cancer risk was 0.92 (95% CI=0.87, 0.97) among sustained quitters and 0.97 (95% CI=0.91, 1.03) among new quitters relative to that among sustained smokers. This study found a significant association between changes in smoking behavior and cancer risk. These findings suggest that smoking cessation is critical for cancer prevention in women.
ISSN:0749-3797
1873-2607
DOI:10.1016/j.amepre.2022.07.001