Interplay of gut microbiome, fatty acids, and the endocannabinoid system in regulating development, progression, immunomodulation, and chemoresistance of cancer

•Molecular hierarchy: gut microbiome, metabolite PUFA, endocannabinoids on cancer The roles of gut microorganisms in cancer are diverse. Studies on metagenomics and bioinformatics have documented diverse microbial etiology in different tumors. Evidence supports that a commensal microbiome could prov...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2022-11, Vol.103-104, p.111787-111787, Article 111787
Main Authors: Nandi, Sourav Kumar, Basu, Sudarshana, Bhattacharjya, Anish, Dey Ghosh, Ruma, Bose, Chinmoy Kumar, Mukhopadhyay, Soma, Bhattacharya, Rittwika
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Bioinformatics
Biosynthesis
Cancer
Cell death
Cell survival
Chemoresistance
Chemotherapy
Cytokines
Dendritic cells
Detoxification
Digestive system
Drugs
Endocannabinoid system
Enzymes
Epigenetics
Estrogens
Etiology
Fatty acids
Fecal microbial transplantation
Growth factors
Gut microbiome
Immune checkpoint inhibitor
Immune response
Immune system
Immunomodulation
Immunotherapy
Influence
Intestinal microflora
Ligands
Lipopolysaccharide
Lymphocytes
Metabolism
Metabolites
Metagenomics
Microbiomes
Microbiota
Microorganisms
Neurotransmitters
Pathogens
Physiology
Polyunsaturated fatty acids
Prevention
Regulation
Signaling
Therapeutic applications
Tumor microenvironment
Tumorigenesis
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Molecular hierarchy: gut microbiome, metabolite PUFA, endocannabinoids on cancer The roles of gut microorganisms in cancer are diverse. Studies on metagenomics and bioinformatics have documented diverse microbial etiology in different tumors. Evidence supports that a commensal microbiome could provide a promising strategy to treat and prevent cancer through interference in several biologic processes, such as host cell survival and death, host immune function, inflammation, oncogenic signaling, and several hormone receptor signaling and detoxification pathways. The cumulative evidence recommends that metabolites of commensal gut microorganisms (e.g., short-chain fatty acids, omega-3 and -6 fatty acids) play an important role in cancer prevention, with a robust antiproliferative effect of omega-3 fatty acids. Intriguingly, the endocannabinoid system (omega-3 and -6 fatty acid-derived neurotransmitter of the body) shows diverse effects on cancer prevention and oncogenesis depending on the context of the tumor microenvironment. Thus, an interplay of gut microorganisms with their fatty acid metabolites and the endocannabinoid system play an important role in the development, progression, immunomodulation, and chemoresistance of cancer. In this review, we highlight aspects of the current knowledge of and interactions between the microbiome with fatty acids and the host endocannabinoid system. We also document their effect on host immunomodulation and chemoresistance, and discuss how these insights might translate into future development of microbiome-targeted therapeutic interventions.
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2022.111787