Timing of Vasopressin Addition to Norepinephrine and Efficacy Outcomes in Patients With Septic Shock

Background: Current guidelines recommend norepinephrine as the first-line vasopressor in septic shock followed by addition of vasopressin to achieve a goal mean arterial pressure. Limited evidence exists evaluating how the timing of vasopressin addition affects clinical outcomes in septic shock. Obj...

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Bibliographic Details
Published in:The Annals of pharmacotherapy 2023-05, Vol.57 (5), p.521-526
Main Authors: Brask, Allison L., Shemanski, Shelby M., Barnes, Tyler E., Holmes, Ashley K.
Format: Article
Language:English
Subjects:
Addiction Medicine
Adult
Humans
Norepinephrine - therapeutic use
Retrospective Studies
Shock, Septic - drug therapy
Vasoconstrictor Agents - therapeutic use
Vasopressins - therapeutic use
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Summary:Background: Current guidelines recommend norepinephrine as the first-line vasopressor in septic shock followed by addition of vasopressin to achieve a goal mean arterial pressure. Limited evidence exists evaluating how the timing of vasopressin addition affects clinical outcomes in septic shock. Objective: The objective of this study was to determine whether the timing of the addition of vasopressin to norepinephrine affects shock resolution. Methods: This was a multi-site, single system, retrospective cohort, institutional review board (IRB)-approved study examining adult patients with septic shock who received norepinephrine and vasopressin. Patients were divided and statistically analyzed in two subgroups: early vasopressin addition (
ISSN:1060-0280
1542-6270
DOI:10.1177/10600280221118903