Brain-derived neurotrophic factor (BDNF): a multifaceted marker in chronic kidney disease

Despite advances in diagnostic tools and therapeutic options, chronic kidney disease (CKD) is still a global health problem associated with increased morbidity and mortality. Insulin resistance, muscle wasting, malnutrition and chronic inflammation are highly prevalent in CKD patients. Brain-derived...

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Bibliographic Details
Published in:Clinical and experimental nephrology 2022-12, Vol.26 (12), p.1149-1159
Main Authors: Afsar, Baris, Afsar, Rengin Elsurer
Format: Article
Language:English
Subjects:
Beta cells
Brain-derived neurotrophic factor
Cell differentiation
Inflammation
Insulin resistance
Kidney diseases
Malnutrition
Medicine
Medicine & Public Health
Morbidity
Nephrology
Nerve growth factor
Neural networks
Neural plasticity
Oxidative stress
Population studies
Public health
Review Article
Synaptic plasticity
Tropomyosin
Urology
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Summary:Despite advances in diagnostic tools and therapeutic options, chronic kidney disease (CKD) is still a global health problem associated with increased morbidity and mortality. Insulin resistance, muscle wasting, malnutrition and chronic inflammation are highly prevalent in CKD patients. Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor-related family and with its receptor tropomyosin-related kinase receptor B impacts cell differentiation, synaptic connectivity and plasticity of the brain. BDNF is well studied in various populations especially in the area of neurology and psychiatry. Recently, there is also an acceleration of BDNF research in CKD and accumulating evidence suggests that BDNF may be a potential prognostic marker in CKD patients. Specifically, studies have shown that BDNF is associated with insulin resistance, muscle wasting, depression, oxidative stress and inflammation in CKD patients. However, the data regarding BDNF in CKD is only in its first steps and various issues must be highlighted in upcoming studies. In this review, we have summarized the findings regarding BDNF and its relationship between insulin resistance, muscle wasting, depression, oxidative stress and inflammation in CKD patients. We also mentioned controversies and possible causes for diverse findings and suggest perspectives in the context of BDNF and CKD.
ISSN:1342-1751
1437-7799
DOI:10.1007/s10157-022-02268-z