Nucleic acid-based therapeutics for dermal wound healing

Non-healing wounds have long been the subject of scientific and clinical investigations. Despite breakthroughs in understanding the biology of delayed wound healing, only limited advances have been made in properly treating wounds. Recently, research into nucleic acids (NAs) such as small-interferin...

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Bibliographic Details
Published in:International journal of biological macromolecules 2022-11, Vol.220, p.920-933
Main Authors: Sharma, Preety, Kumar, Arun, Agarwal, Tarun, Dey, Asmita Deka, Moghaddam, Farnaz Dabbagh, Rahimmanesh, ILNAZ, Ghovvati, Mahsa, Yousefiasl, Satar, Borzacchiello, Assunta, Mohammadi, Abbas, Yella, Venkata Rajesh, Moradi, Omid, Sharifi, Esmaeel
Format: Article
Language:English
Subjects:
Biomaterials
Nanomedicine
Nucleic acid delivery
Oligonucleotides
Wound healing
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Summary:Non-healing wounds have long been the subject of scientific and clinical investigations. Despite breakthroughs in understanding the biology of delayed wound healing, only limited advances have been made in properly treating wounds. Recently, research into nucleic acids (NAs) such as small-interfering RNA (siRNA), microRNA (miRNA), plasmid DNA (pDNA), aptamers, and antisense oligonucleotides (ASOs) has resulted in the development of a latest therapeutic strategy for wound healing. In this regard, dendrimers, scaffolds, lipid nanoparticles, polymeric nanoparticles, hydrogels, and metal nanoparticles have all been explored as NA delivery techniques. However, the translational possibility of NA remains a substantial barrier. As a result, different NAs must be identified, and their distribution method must be optimized. This review explores the role of NA-based therapeutics in various stages of wound healing and provides an update on the most recent findings in the development of NA-based nanomedicine and biomaterials, which may offer the potential for the invention of novel therapies for this long-term condition. Further, the challenges and potential for miRNA-based techniques to be translated into clinical applications are also highlighted. [Display omitted]
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2022.08.099