Effects of taurine on vascular tone

Taurine is widely distributed at high concentrations in mammalian tissues, and it plays an important role in a wide range of biological effects including modulation of cardiovascular functions. This review summarizes the role of taurine in vascular tone and blood pressure modulation based on experim...

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Bibliographic Details
Published in:Amino acids 2022-12, Vol.54 (12), p.1527-1540
Main Authors: Yildiz, Oguzhan, Ulusoy, Kemal Gokhan
Format: Article
Language:English
Subjects:
Analytical Chemistry
Animal models
Arteries
Biochemical Engineering
Biochemistry
Biological effects
Biomedical and Life Sciences
Blood pressure
Calcium channels
Calcium conductance
Calcium ions
Channels
Endothelium
Hypertension
Invited Review
Life Sciences
Modulation
Neurobiology
Potassium channels (calcium-gated)
Potassium conductance
Proteomics
Taurine
Vascular diseases
Vascular system
Vasodilation
Veins & arteries
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Summary:Taurine is widely distributed at high concentrations in mammalian tissues, and it plays an important role in a wide range of biological effects including modulation of cardiovascular functions. This review summarizes the role of taurine in vascular tone and blood pressure modulation based on experimental and human studies. It is well established that supplementation of taurine prevents development of hypertension in several animal models and p.o. taurine administration reduces blood pressure in hypertensive patients. Both central and peripheral actions of taurine may be involved in its hypotensive effects. In isolated animal arteries, taurine exerts vasodilation through endothelium-dependent and independent mechanisms. Several studies showed that taurine relaxed various animal arteries through opening potassium channels. We have recently shown that taurine relaxes human internal mammary and radial arteries by opening large conductance Ca 2+ -activated K + channels. To date, the molecular mechanism(s) involved in the vascular effects of taurine are largely unknown and require further investigation. Clarifying the mechanisms in which taurine affects the vascular system may facilitate the development of therapeutic and/or diet-based strategies to reduce the burden of vascular diseases.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-022-03198-6