The fibrosis‐4 score is associated with long‐term mortality in different phenotypes of acute heart failure

Background Fibrosis‐4 score (FIB4) was a non‐invasive surrogate to estimate the amount of liver scarring in chronic hepatitis. Considering the presence of increased central venous pressure and congestive hepatopathy in patients with decompensated heart failure, we therefore investigated the prognost...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical investigation 2022-12, Vol.52 (12), p.e13856-n/a
Main Authors: Tseng, Chih‐Hsueh, Huang, Wei‐Min, Yu, Wen‐Chung, Cheng, Hao‐Min, Chang, Hao‐Chih, Hsu, Pai‐Feng, Chiang, Chern‐En, Chen, Chen‐Huan, Sung, Shih‐Hsien
Format: Article
Language:English
Subjects:
acute heart failure
Alanine
Alanine transaminase
Aspartate aminotransferase
Cardiovascular disease
Comorbidity
Congestive heart failure
Coronary artery disease
Death
Ejection fraction
FIB4
Fibrosis
fibrosis‐4 score
Glomerular filtration rate
Heart diseases
Heart failure
Hemoglobin
Hepatitis
HFpEF
liver stiffness
Mortality
Phenotypes
Transaminases
Ventricle
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Fibrosis‐4 score (FIB4) was a non‐invasive surrogate to estimate the amount of liver scarring in chronic hepatitis. Considering the presence of increased central venous pressure and congestive hepatopathy in patients with decompensated heart failure, we therefore investigated the prognostic values of FIB4 in acute heart failure (AHF) patients. Method Patients hospitalised primarily for HF were drawn from an intramural registry. FIB4 was calculated according to age, aspartate aminotransferase, alanine aminotransferase and platelet count. All‐cause mortality up to 5 years after discharge was obtained by linking to the national death registry. Results Among a total of 1854 participants, 940 patients died during a mean follow‐up of 28.3 ± 21.8 months. FIB4 score was related to mortality and the composite of cardiovascular death or HF rehospitalisation, independent of age, sex, left ventricular ejection fraction, left atrial dimension, sodium and haemoglobin levels, estimated glomerular filtration rate, comorbidities, and medications [hazard ratio and 95% confidence interval of mortality: 1.009 (1.002–1.015), and the composite of cardiovascular death or HF hospitalisation: 1.020 (1.010–1.031)]. The prognostic value of FIB4 was predominantly in the subjects with heart failure and preserved or mildly reduced ejection fraction (HFpEF and HFmrEF), or coronary artery disease (CAD) than the counterparts [interaction p‐value
ISSN:0014-2972
1365-2362
DOI:10.1111/eci.13856