A Water‐Soluble Antimony‐Rich Polyoxometalate with Broad‐Spectrum Antitumor Activities

Herein, a giant Sb‐rich polyoxometalate (POM) {Sb21Tb7W56} is reported, which contains the largest number of Sb atoms in a POM so far. The Sb‐rich POM has many interesting structural features and is a rare example of a soluble and water‐stable giant POM. Biomedical studies indicate that the Sb‐rich...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2022-10, Vol.61 (41), p.e202210019-n/a
Main Authors: Xiao, Hui‐Ping, Hao, Ya‐Shuai, Li, Xin‐Xiong, Xu, Peng, Huang, Ming‐Dong, Zheng, Shou‐Tian
Format: Article
Language:English
Subjects:
Anticancer properties
Antimony
Antineoplastic drugs
Antitumor activity
Antitumor Agents
Antitumor Mechanism
Apoptosis
Atomic properties
Biomedical materials
Breast cancer
Drug development
Heterometallic Clusters
Metastases
Mitochondria
Polyoxometalates
Polyoxometallates
Tumor cell lines
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Summary:Herein, a giant Sb‐rich polyoxometalate (POM) {Sb21Tb7W56} is reported, which contains the largest number of Sb atoms in a POM so far. The Sb‐rich POM has many interesting structural features and is a rare example of a soluble and water‐stable giant POM. Biomedical studies indicate that the Sb‐rich POM exhibits broad‐spectrum antitumor activity against various cancer cell lines by reactivating the P53‐dependent apoptotic processes and disrupting the mitochondrial membrane. In addition, this Sb‐rich POM was capable of suppressing the growth and metastasis of a breast cancer in vivo. This work demonstrates that Sb‐rich POMs are promising candidates for the development of new anticancer drugs. A novel soluble and water‐stable giant Sb‐rich polyoxometalate (POM) has been developed, which shows the largest Sb−Ln−W cluster and has the greatest number of Sb centers in a cluster yet found in POM chemistry. Importantly, the Sb‐rich POM can exhibit broad‐spectrum antitumor and anti‐metastatic activities in vitro and in vivo without causing adverse effects, making it a promising candidate for a antitumor agent.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202210019