Somatosensory targeted memory reactivation enhances motor performance via hippocampal-mediated plasticity

Abstract Increasing evidence suggests that reactivation of newly acquired memory traces during postlearning wakefulness plays an important role in memory consolidation. Here, we sought to boost the reactivation of a motor memory trace during postlearning wakefulness (quiet rest) immediately followin...

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Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2023-03, Vol.33 (7), p.3734-3749
Main Authors: Veldman, Menno P, Dolfen, Nina, Gann, Mareike A, Van Roy, Anke, Peeters, Ronald, King, Bradley R, Albouy, Geneviève
Format: Article
Language:English
Subjects:
Brain - physiology
Hippocampus - diagnostic imaging
Humans
Learning - physiology
Memory - physiology
Memory Consolidation - physiology
Sleep - physiology
Young Adult
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Summary:Abstract Increasing evidence suggests that reactivation of newly acquired memory traces during postlearning wakefulness plays an important role in memory consolidation. Here, we sought to boost the reactivation of a motor memory trace during postlearning wakefulness (quiet rest) immediately following learning using somatosensory targeted memory reactivation (TMR). Using functional magnetic resonance imaging, we examined the neural correlates of the reactivation process as well as the effect of the TMR intervention on brain responses elicited by task practice on 24 healthy young adults. Behavioral data of the post-TMR retest session showed a faster learning rate for the motor sequence that was reactivated as compared to the not-reactivated sequence. Brain imaging data revealed that motor, parietal, frontal, and cerebellar brain regions, which were recruited during initial motor learning, were specifically reactivated during the TMR episode and that hippocampo-frontal connectivity was modulated by the reactivation process. Importantly, the TMR-induced behavioral advantage was paralleled by dynamical changes in hippocampal activity and hippocampo-motor connectivity during task practice. Altogether, the present results suggest that somatosensory TMR during postlearning quiet rest can enhance motor performance via the modulation of hippocampo-cortical responses.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhac304