Mesoporous silica nanoparticles incorporated with Ir(III) complexes: From photophysics to photodynamic therapy

•Efficient encapsulation of Ir complexes inside the MCM41@COOH.•High protection of complexes inside mesopores, drastically reducing their intrinsic toxicity.•High amounts of singlet oxygen after light irradiation.•Low toxicity in healthy and cancerous strains in the absence of light.•High cellular t...

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Bibliographic Details
Published in:Photodiagnosis and photodynamic therapy 2022-12, Vol.40, p.103052-103052, Article 103052
Main Authors: Estevão, Bianca M., Vilela, Raquel R.C., Geremias, Isabella P., Zanoni, Kassio P.S., de Camargo, Andrea S.S., Zucolotto, Valtencir
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Ir(III) complexes
Liver cancer
Mesoporous silica nanoparticles
Nanoparticles
PDT
Photochemotherapy - methods
Photodynamic Therapy
Photophysics
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
Silicon Dioxide
Singlet Oxygen
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Summary:•Efficient encapsulation of Ir complexes inside the MCM41@COOH.•High protection of complexes inside mesopores, drastically reducing their intrinsic toxicity.•High amounts of singlet oxygen after light irradiation.•Low toxicity in healthy and cancerous strains in the absence of light.•High cellular toxicity in the presence of light, short lighting time and low concentration of nanoparticles. Organically modified mesoporous silica nanoparticles (MSNs) containing Ir complexes (Ir1, Ir2 and Ir3) were successfully synthesized. These Ir‐entrapped MCM41-COOH nanoparticles have shown relevant photophysical characteristics including high efficiency in the photoproduction and delivery of singlet oxygen (1O2), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that complex@MCM41-COOH are able to reduce cell proliferation after 10 min of blue‐light irradiation in Hep-G2 liver cancer cells. [Display omitted]
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2022.103052