Targeting disrupted rich-club network organization with neuroplasticity-based computerized cognitive remediation in major depressive disorder patients

•This study confirmed the efficacy of neuroplasticity-based computerized cognitive remediation (nCCR) on executive function in patients with major depressive disorder (MDD).•The MDD patients in the nCCR group over 4 weeks showed increased the number of rich-club connections, global efficiency, and t...

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Published in:Psychiatry research 2022-10, Vol.316, p.114742-114742, Article 114742
Main Authors: Shu, Min, Feng, Suyang, Liu, Jiacheng
Format: Article
Language:English
Subjects:
Brain structural connectome
Cognitive training
Major depressive disorder
Network efficiency
Rich club organization
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Summary:•This study confirmed the efficacy of neuroplasticity-based computerized cognitive remediation (nCCR) on executive function in patients with major depressive disorder (MDD).•The MDD patients in the nCCR group over 4 weeks showed increased the number of rich-club connections, global efficiency, and the SC-FC coupling strength compared to the control group.•Significant correlations between brain network topological parameters and TMT scores revealed increased executive function after cognitive training. Disrupted rich-club organization has been extensively studied in major depressive disorder (MDD) patients. Although data indicate that neuroplasticity-based computerized cognitive remediation (nCCR) can accelerate clinical responses in MDD patients, the mechanisms underlying its antidepressant efficacy are unknown. In this study, all MDD patients underwent two (baseline and week 4) neuropsychological assessments and DTI imaging. Additionally, 17 MDD patients did nCCR for 30 hours spread across 4 weeks. Rich-club organization was calculated with a graph-theoretical approach, and SC-FC coupling was explored. After 4 weeks of treatment, the number of rich-club connections, global efficiency, and SC-FC coupling strength increased significantly and were negatively associated with TMT-B scores. The effects of nCCR on disrupted rich-club organization may partly underlie its efficacy in improving the executive function of patients with MDD. Effects of nCCR on disrupted rich-club organization may partly underlie its efficacy in improving the executive function of patients with MDD.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2022.114742