Microwave‐Assisted Three‐Component Synthesis of Novel N‐Arylated‐Dihydrobenzo[g]quinoline‐5,10‐Diones and Their Potential Cytotoxic Activity

A convenient three‐component synthetic approach was developed en route to new and significative N‐arylated‐dihydrobenzo[g]quinoline‐5,10‐diones using 2‐hydroxy‐1,4‐naphthoquinone, a variety of aromatic aldehydes, and 4‐(arylamino)furan‐2(5H)‐ones. A sequence of steps including Knoevenagel condensati...

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Published in:Chemistry & biodiversity 2022-08, Vol.19 (8), p.e202200359-n/a
Main Authors: Nguyen, Ha Thanh, Le‐Nhat‐Thuy, Giang, Thi, Phuong Hoang, Thi, Quynh Giang Nguyen, Nguyen, Tuan Anh, Thi, Thu Ha Nguyen, Thi, Tuyet Anh Dang, Nguyen, Tuyen Van
Format: Article
Language:English
Subjects:
aza-anthraquinone
cytotoxicity profile
microwave-assisted three-component reaction
N-arylated-dihydrobenzo[g]quinoline-5,10-diones
γ-butyrolactone
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Summary:A convenient three‐component synthetic approach was developed en route to new and significative N‐arylated‐dihydrobenzo[g]quinoline‐5,10‐diones using 2‐hydroxy‐1,4‐naphthoquinone, a variety of aromatic aldehydes, and 4‐(arylamino)furan‐2(5H)‐ones. A sequence of steps including Knoevenagel condensation, Michael addition, [1,3]‐hydrogen shift, intramolecular cyclization and dehydration led to the formation of products. All the products were structurally characterized by spectroscopic techniques and assessed in terms of their cytotoxicity profile against four cancer cell lines (KB, HepG2, A549, and MCF7), and human embryonic kidney (Hek‐293) cell lines.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202200359