Tracheostomized children tracheal colonization and antibiotic resistance profile – A STROBE analysis

To verify the prevalence of Potentially pathogenic bacteria (PPB) and their antimicrobial resistance profile in tracheal aspirates of children with tracheostomy and compare it to clinical data. A cross-sectional study was conducted in patients aged 0–18 years who all underwent tracheostomy cannula c...

Full description

Saved in:
Bibliographic Details
Published in:European annals of otorhinolaryngology, head and neck diseases head and neck diseases, 2023-03, Vol.140 (2), p.71-76
Main Authors: Vasconcellos Severo, G., Schweiger, C., Manica, D., Marostica, P.J.C.
Format: Article
Language:English
Subjects:
Airway
Airway culture
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Cefepime
Child
Child, Preschool
Children
Cross-Sectional Studies
Drug Resistance, Microbial
Gentamicins
Humans
Microbial Sensitivity Tests
Pseudomonas aeruginosa
Tracheal aspirate
Tracheostomy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To verify the prevalence of Potentially pathogenic bacteria (PPB) and their antimicrobial resistance profile in tracheal aspirates of children with tracheostomy and compare it to clinical data. A cross-sectional study was conducted in patients aged 0–18 years who all underwent tracheostomy cannula change (TCC) performed by the Otolaryngology Unit at Hospital de Clínicas de Porto Alegre, Brazil, between October, 2017 and December, 2018. Patients were submitted, at the time of TCC, to a tracheal aspirate through the tracheostomy and secretion was sent to microbiological analysis and antimicrobial susceptibility testing. Clinical data were evaluated through available patients’ electronic medical records. Forty-four patients had their tracheostomy aspirate cultured and all but one presented PPB growth (97.7%). Median age was 3 years-old. Pseudomonas aeruginosa was the most prevalent bacteria (56.9%) and it was resistant to gentamycin, amikacin and cefepime in 36%, 28% and 12% of the culture tests, respectively. P. aeruginosa resistance to gentamycin and to cefepime suggested an association with the number of antibiotic classes used in the 12 months before enrollment (both p=0.04) and with 2 or more hospital admissions in the same period (p=0.03 and p=0.02, respectively). Staphylococcus aureus was isolated in 9.1% and there was no MRSA. It was found a 97.7% prevalence of PPB in the cultured aspirates; the most prevalent bacterium was P. aeruginosa and there was no MRSA identification. Data suggest an association between P. aeruginosa antimicrobial resistance with previous use of antibiotic therapy.
ISSN:1879-7296
1879-730X
DOI:10.1016/j.anorl.2022.07.002