Impact of HPV status on nutritional status during radio chemotherapy for oropharyngeal cancer

Patients with oropharyngeal cancer are at high nutritional risk before and during treatment. Little is known about the influence of human papillomavirus (HPV) infection on nutritional status and its evolution during treatment. A single-center retrospective study was conducted between August 2017 and...

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Bibliographic Details
Published in:Cancer radiothérapie 2023-02, Vol.27 (1), p.42-49
Main Authors: Saroul, N, Martraix, C, Mulliez, A, Cassagnes, L, Puechmaille, M, Bernadach, M, Biau, J, Walrand, S, Lapeyre, M
Format: Article
Language:fre
Subjects:
Carcinoma, Squamous Cell - therapy
Head and Neck Neoplasms
Humans
Nutritional Status
Oropharyngeal Neoplasms - therapy
Papillomavirus Infections - complications
Retrospective Studies
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Summary:Patients with oropharyngeal cancer are at high nutritional risk before and during treatment. Little is known about the influence of human papillomavirus (HPV) infection on nutritional status and its evolution during treatment. A single-center retrospective study was conducted between August 2017 and December 2020 including 48 patients (14 HPV-induced: HPV+ and 34 non-HPV-induced: HPV-) with oropharyngeal squamous cell carcinoma treated by radiotherapy±chemotherapy (RT/CT). Nutritional risk at the time of tumor assessment (TA) was assessed by weight loss, swallowing ability, and the presence of digestive disorders in 4 stages of increasing severity. Nutritional status was assessed by weight and nutrition risk index (NRI) at the time of TA, before the start and at 3 months from the end of RT±CT. During RT±CT, the NRI and the systemic inflammatory response index (SIRI=neutrophils * monocytes/lymphocytes) were assessed weekly. HPV+patients were at lower nutritional risk at TA (50% grade ≥2 vs 85%, P=0.02), lost more weight (6% of their body weight vs 3%, P=0.05), and increased their SIRI by 7.5 points more than HPV- patients (P=0.04) during RT/CT. HPV+ oropharyngeal cancer patients are at high nutritional risk even in the absence of undernutrition at the outset of management.
ISSN:1769-6658
DOI:10.1016/j.canrad.2022.05.002