Analysis of genetic variants of frequently mutated genes in human papillomavirus‐negative primary head and neck squamous cell carcinoma, resection margins, local recurrences and corresponding circulating cell‐free DNA

Background Head and neck squamous cell carcinoma remains a substantial burden to global health. Despite evolving therapies, 5‐year survival is

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Bibliographic Details
Published in:Journal of oral pathology & medicine 2022-09, Vol.51 (8), p.738-746
Main Authors: Flach, Susanne, Kumbrink, Jörg, Walz, Christoph, Hess, Julia, Drexler, Guido, Belka, Claus, Canis, Martin, Jung, Andreas, Baumeister, Philipp
Format: Article
Language:English
Subjects:
Cancer
Cdc4 protein
cell‐free DNA
DNA fingerprinting
Genetic analysis
Genetic diversity
Head & neck cancer
Head and neck carcinoma
HNSCC
Human papillomavirus
liquid biopsy
Mutation
next‐generation sequencing
Notch1 protein
p53 Protein
Patients
Public health
resection margins
Squamous cell carcinoma
Tumors
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Description
Summary:Background Head and neck squamous cell carcinoma remains a substantial burden to global health. Despite evolving therapies, 5‐year survival is
ISSN:0904-2512
1600-0714
DOI:10.1111/jop.13338