Low-dose statins improve prognosis of patients with ischaemic stroke undergoing intra-arterial thrombectomy: A prospective cohort study

•High-dose statins are recommended as preventive drugs in guidelines for patients with ischaemic stroke undergoing thrombectomy. Some studies have found that the use of high-intensity statins is associated with cerebral haemorrhage in patients with ischaemic stroke treated with thrombolysis. Low-dos...

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Published in:Journal of clinical neuroscience 2022-09, Vol.103, p.124-130
Main Authors: Cui, Chaohua, Dong, Shuju, Liu, Qian, Bao, Jiajia, Gao, Lijie, Li, Yanbo, He, Li
Format: Article
Language:English
Subjects:
Efficacy and safety
Intra-arterial thrombectomy
Low-dose statin
Stroke
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Summary:•High-dose statins are recommended as preventive drugs in guidelines for patients with ischaemic stroke undergoing thrombectomy. Some studies have found that the use of high-intensity statins is associated with cerebral haemorrhage in patients with ischaemic stroke treated with thrombolysis. Low-dose statins have been widely used and demonstrated to be efficient in Asian populations. However, it remains unknown whether low-dose statin is related to the prognosis of patients with thrombectomy. Can low-dose statins reduce the risk of bleeding at the same time?•We found that in Asian acute ischaemic stroke patients with intra-arterial thrombectomy, low-dose statin use was significantly related to NIHSS improvement at 7 days, FFO at 90 days and decreased death rates within 2 years. High-dose statins are recommended as preventive drugs in guidelines for patients with ischaemic stroke undergoing thrombectomy. Not only in clinical practice but also based on large-scale studies, low-dose statins have been widely used and demonstrated to be efficient in Asian populations. However, it remains unknown whether a low-dose statin is related to the prognosis of patients with thrombectomy. Can low-dose statins reduce the risk of bleeding at the same time? We prospectively collected data from patients with acute ischaemic stroke undergoing intra-arterial thrombectomy. Efficacy outcomes were National Institutes of Health Stroke Scale (NIHSS) score improvement at 7 days after admission and a favourable functional outcome (FFO) at 90 days. Safety outcomes were rates of in-hospital haemorrhage events and death within 2 years. We included 256 patients in this study. Compared with the control group, the low-dose statin group had a higher NIHSS improvement rate at 7 days, a higher FFO rate at 90 days and a lower death rate within 2 years. The low-dose statin group had a lower percentage of gastrointestinal haemorrhage. Statin use was significantly related to an improved NIHSS score (p = 0.028, OR = 1.773) at 7 days and FFO (P 
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2022.07.001