Local Patterns in 2‐Year T1ρ and T2 Changes of Hip Cartilage Are Related to Sex and Functional Data: A Prospective Evaluation on Hip Osteoarthritis Participants

Background Although T1ρ and T2 have emerged as early indicators for hip osteoarthritis (OA), there is little information regarding longitudinal changes across the cartilage in the early stages of this disease. Purpose To characterize the variability in 2‐year hip cartilage T1ρ and T2 changes and inv...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2023-04, Vol.57 (4), p.1042-1053
Main Authors: Roach, Koren E., Souza, Richard B., Majumdar, Sharmila, Pedoia, Valentina
Format: Article
Language:English
Subjects:
Arthritis
Biomedical materials
Body mass
Body mass index
Body size
Cartilage
Cartilage diseases
Correlation
Evaluation
Femur
Field strength
Functional testing
Hip
hip osteoarthritis
Indicators
Magnetic resonance imaging
Men
Osteoarthritis
Population studies
principal component analysis
Sex
Statistical analysis
Statistical tests
voxel‐based T1ρ/T2 quantification
Women
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Summary:Background Although T1ρ and T2 have emerged as early indicators for hip osteoarthritis (OA), there is little information regarding longitudinal changes across the cartilage in the early stages of this disease. Purpose To characterize the variability in 2‐year hip cartilage T1ρ and T2 changes and investigate associations between these patterns of change and common indicators of hip OA. Study Type Prospective. Population A total of 25 women (age: 51.9 ± 16.3 years old; BMI: 22.6 ± 2.0 kg/m2) and 17 men (age: 55.8 ± 14.9 years old; body mass index (BMI): 24.4 ± 3.8 kg/m2) who were healthy or with early‐to‐moderate hip OA. Field Strength/Sequence A 3 T MRI (GE), 3D combined T1ρ/T2 magnetization‐prepared angle‐modulated partitioned k‐space spoiled gradient echo snapshots. Assessment Principal component (PC) analysis of Z‐score difference maps of 2‐year changes in hip cartilage T1ρ and T2 relaxation times, participant hip disability and osteoarthritis outcome scores (HOOS) and functional tests at 2‐year follow‐up. Statistical Tests Shapiro–Wilk test, unpaired t‐tests, Kruskal Wallis tests, Pearson or Spearman (ρ) correlations. Significance was set at P 
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.28347