CASC15 Gene Polymorphisms and Glioma Susceptibility in Chinese Children

Objective Gliomas are the most common tumors in the central nervous system. The cancer susceptibility candidate 15 ( CASC15 ) gene has been reported to be a susceptibility gene for several types of cancer. No studies have been carried out on the predisposing effect of CASC15 gene single nucleotide p...

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Published in:Current medical science 2022-08, Vol.42 (4), p.797-802
Main Authors: Lin, Hui-ran, Chen, Yong-ping, Chen, Hui-tong, Liu, Xiao-ping, Zhou, Jing-ying, Huang, Xiao-kai, Yuan, Li, Zhuo, Zhen-jian
Format: Article
Language:English
Subjects:
Asian People - genetics
Child, Preschool
Genetic Predisposition to Disease
Genotype
Glioma - genetics
Humans
Medicine
Medicine & Public Health
Polymorphism, Single Nucleotide - genetics
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Summary:Objective Gliomas are the most common tumors in the central nervous system. The cancer susceptibility candidate 15 ( CASC15 ) gene has been reported to be a susceptibility gene for several types of cancer. No studies have been carried out on the predisposing effect of CASC15 gene single nucleotide polymorphisms (SNPs) on glioma risk. Methods In order to determine whether CASC15 gene SNPs are involved in glioma susceptibility, the first association study in a relatively large sample, which consisted of 171 patients and 228 healthy controls recruited from China, was performed. The contribution of SNPs (rs6939340 A>G, rs4712653 T>C and rs9295536 C>A) to the risk of glioma was evaluated by multinomial logistic regression, based on the calculation of the odds ratio (OR) and 95% confidence interval (CI). Results In the single locus and combined analysis, it was revealed that the genetic risk score had no significant associations between CASC15 gene SNPs and glioma risk. However, in the stratified analysis, a significant decrease in risk of glioma was observed in subjects of
ISSN:2096-5230
2523-899X
DOI:10.1007/s11596-022-2613-5