Action mechanisms of metallic compounds on Plasmodium spp

BACKGROUNDMalaria is a parasitic disease with the highest morbidity and mortality worldwide. Unfortunately, during the last decades, the causal agent, Plasmodium spp., has developed resistance to chloroquine and artemisinin. For this reason, metallic compounds have been proposed as an optional treat...

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Published in:Journal of trace elements in medicine and biology 2022-09, Vol.73, p.127028-127028, Article 127028
Main Authors: Brenda, Casarrubias-Tabarez, Norma, Rivera-Fernández, Marcela, Rojas-Lemus, Nelly, López-Valdez, Teresa I, Fortoul
Format: Article
Language:English
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Summary:BACKGROUNDMalaria is a parasitic disease with the highest morbidity and mortality worldwide. Unfortunately, during the last decades, the causal agent, Plasmodium spp., has developed resistance to chloroquine and artemisinin. For this reason, metallic compounds have been proposed as an optional treatment since they have shown a potential antimalarial effect with diverse action mechanisms in the parasite and the host. OBJECTIVETo show the possible targets of metallic compounds in Plasmodium spp. CONCLUSIONThe metallic compounds are an option attractive to treatment for the malaria, for its low cost and its great activity to reduce parasitemia; however is necessary more studies principally in vivo in order to know the interactions that it can have in an experimental model.
ISSN:0946-672X
1878-3252
DOI:10.1016/j.jtemb.2022.127028