The viscoelastic characteristics of in-vitro carotid plaque by Kelvin-Voigt fractional derivative modeling

Atherosclerotic plaque with a thin fibrous cap can be ruptured by shear force. Exploiting the mechanical properties of plaques within different histological regions can help to better understand the physical mechanisms of the plaque. The association between the plaque components and viscoelasticity...

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Bibliographic Details
Published in:Journal of biomechanics 2022-08, Vol.141, p.111210-111210, Article 111210
Main Authors: Zhou, Yan, Song, Yan, Liu, Zhihui, Li, Wenbin, Guo, Ying, Matkovic, Luke A., Yang, Xiaofeng, Ma, Ruining, Wan, Mingxi, Ruan, Litao, Zhang, Hongmei
Format: Article
Language:English
Subjects:
Arteriosclerosis
Atherosclerosis
Carotid plaque
Collagen
Correlation
Degeneration
Extracellular matrix
Fluidity
Inflammation
Kelvin-Voigt fractional derivative (KVFD) model
Lipids
Mechanical properties
Modelling
Modulus of elasticity
Nanoindentation
Necrosis
Plaques
Risk of vulnerability
Shear forces
Software
Testing laboratories
Viscoelastic measurement
Viscoelasticity
Viscosity
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Summary:Atherosclerotic plaque with a thin fibrous cap can be ruptured by shear force. Exploiting the mechanical properties of plaques within different histological regions can help to better understand the physical mechanisms of the plaque. The association between the plaque components and viscoelasticity was studied when mapping the viscoelasticity to histological features. Eleven in-vitro carotid plaques were tested with ramp-hold relaxation nanoindentation tests. Viscoelasticity (elastic modulus E0, fluidity α, and viscosity τ) was characterized by Kelvin-Voigt fractional derivative (KVFD) modeling. There is a significant difference (p 
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2022.111210