Chronological change in serum albumin as a prognostic factor in patients with hepatocellular carcinoma treated with lenvatinib: proposal of albumin simplified grading based on the modified albumin–bilirubin score (ALBS grade)

Background The albumin–bilirubin (ALBI) score and the modified ALBI (mALBI) grade are known useful prognostic factors for patients with hepatocellular carcinoma (HCC) treated with lenvatinib (LEN-HCC). However, the ALBI score requires complicated logarithmic calculations. Therefore, we attempted to...

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Bibliographic Details
Published in:Journal of gastroenterology 2022-08, Vol.57 (8), p.581-586
Main Authors: Kariyama, Kazuya, Hiraoka, Atsushi, Kumada, Takashi, Yasuda, Satoshi, Toyoda, Hidenori, Tsuji, Kunihiko, Hatanaka, Takeshi, Kakizaki, Satoru, Naganuma, Atsushi, Tada, Toshifumi, Takaguchi, Koichi, Itobayashi, Ei, Ishikawa, Toru, Shimada, Noritomo, Tsutsui, Akemi, Nagano, Takuya, Imai, Michitaka, Nakamura, Shinichiro, Wakuta, Akiko, Miyake, Nozomi, Shiota, Shohei, Nouso, Kazuhiro
Format: Article
Language:English
Subjects:
Abdominal Surgery
Albumin
Biliary Tract
Bilirubin
Care and treatment
Colorectal Surgery
Gastroenterology
Hepatocellular carcinoma
Hepatology
Hepatoma
Liver cancer
Medical prognosis
Medicine
Medicine & Public Health
Original Article―Liver
Pancreas
Predictions
Prognosis
Surgical Oncology
Survival
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Summary:Background The albumin–bilirubin (ALBI) score and the modified ALBI (mALBI) grade are known useful prognostic factors for patients with hepatocellular carcinoma (HCC) treated with lenvatinib (LEN-HCC). However, the ALBI score requires complicated logarithmic calculations. Therefore, we attempted to create a simplified score. Methods We developed the albumin simplified (ALBS) grade that corresponded to mALBI using the data of 5985 newly developed HCC and examined the usefulness of this grading system for the prediction of the prognosis of 678 patients with LEN-HCC. Results The analysis using Cox proportional hazard models revealed that the overall survival of patients with LEN-HCC was not correlated with the total bilirubin but albumin (Alb), which means that the prediction with Alb alone was logical. The ALBS grade cutoffs that corresponded to mALBI grade 1, 2a, 2b, and 3 were Alb ≧ 4.0 g/dL, 4.0 g/dL > Alb ≧3.5 g/dL, 3.5 g/dL > Alb≧2.8 g/dL, and Alb
ISSN:0944-1174
1435-5922
DOI:10.1007/s00535-022-01883-7