Amide Proton Transfer‐Weighted Imaging Combined With Intravoxel Incoherent Motion for Evaluating Microsatellite Instability in Endometrial Cancer

Background Microsatellite instability (MSI), caused by mismatch repair (MMR) protein defects that lead to uncorrectable mismatch bases, results in the accumulation of gene mutations and ultimately to tumors. Preoperative prediction of MSI can provide a basis for personalized and precise treatment of...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2023-02, Vol.57 (2), p.493-505
Main Authors: Ma, Changjun, Tian, Shifeng, Song, Qingling, Chen, Lihua, Meng, Xing, Wang, Nan, Lin, Liangjie, Wang, Jiazheng, Liu, Ailian, Song, Qingwei
Format: Article
Language:English
Subjects:
amide proton transfer weighted
Amides
Cancer
Correlation coefficient
Correlation coefficients
Diffusion coefficient
Diffusion Magnetic Resonance Imaging - methods
Effectiveness
Endometrial cancer
Endometrial Neoplasms - diagnostic imaging
Endometrial Neoplasms - genetics
Endometrium
Evaluation
Female
Field strength
Humans
intravoxel incoherent motion
Magnetic resonance imaging
Medical imaging
Microsatellite Instability
Mismatch repair
Motion
Motion stability
Multivariate analysis
Mutation
Patients
Population studies
Protons
Regression analysis
Retrospective Studies
Stability analysis
Statistical analysis
Statistical tests
Tumors
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Summary:Background Microsatellite instability (MSI), caused by mismatch repair (MMR) protein defects that lead to uncorrectable mismatch bases, results in the accumulation of gene mutations and ultimately to tumors. Preoperative prediction of MSI can provide a basis for personalized and precise treatment of endometrial cancer (EC) patients. Purpose To investigate amide proton transfer weighting (APTw) imaging combined with intravoxel incoherent motion (IVIM) in the assessment of MSI in EC. Study Type Retrospective. Population A total of 71 patients with EC (12 classified as the MSI group and 22 as the microsatellite stabilization [MSS] group after entering and leaving the group standard). Field Strength/Sequence A 3.0 T/IVIM, diffusion‐weighted imaging (DWI) and APTw. Assessment Amide proton transfer (APT) value, apparent diffusion coefficient (ADC), pure diffusion coefficient (D), pseudo diffusion coefficient (D*), and perfusion fraction (f) were calculated and compared between MSI and MSS groups. Statistical Tests The Kendall's W test; Mann–Whitney U‐test; Chi‐square test or Fisher's exact test; logistic regression analysis; Area under the receiver operating characteristic (ROC) curve (AUC); The Delong test; Pearson or Spearman correlation coefficients. The significance threshold was set at P 
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.28287