Recent applications of CBT-Cys click reaction in biological systems

[Display omitted] Click chemistry is a hot topic in many research fields. A biocompatible reaction from fireflies has attracted increasing attention since 2009. Herein, we focus on the firefly-sourced click reaction between cysteine (Cys) and 2-cyanobenzothiazole (2-CBT). This reaction has many exce...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2022-08, Vol.68, p.116881-116881, Article 116881
Main Authors: Zhu, Yuechao, Zhang, Xian, You, Qidong, Jiang, Zhengyu
Format: Article
Language:English
Subjects:
Biocompatible probe
Biorthogonal reaction
CBT-Cys reaction
Click Chemistry
Firefly luciferin
Nanoparticles
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Summary:[Display omitted] Click chemistry is a hot topic in many research fields. A biocompatible reaction from fireflies has attracted increasing attention since 2009. Herein, we focus on the firefly-sourced click reaction between cysteine (Cys) and 2-cyanobenzothiazole (2-CBT). This reaction has many excellent properties, such as rapidity, simplicity and high selectivity, which make it successfully applied in protein labeling, molecular imaging, drug discovery and other fields. Meanwhile, its unique ability to form nanoparticles expands its applications in biological systems. We review its principle, development, and latest applications in the past 5 years and hope this review provides more profound and comprehensive insights to its further application.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2022.116881