Improvement of doxorubicin radioiodination and in-vivo cancer suppression via loading in nanosilver system

This study aimed at improving the radioiodination of doxorubicin (DOX) and its localization in cancer cell for theranostic purposes. To achieve this goal, a composite of DOX with polyvinyl pyrrolidone (PVP) and silver nanoparticles (AgNPs) was prepared. Both DOX and (DOX/PVP/AgNPs) were radiolabelle...

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Bibliographic Details
Published in:Applied radiation and isotopes 2022-09, Vol.187, p.110288-110288, Article 110288
Main Authors: Farrag, Nourihan S., El-Sabagh, Hanan A., Al-mahallawi, Abdulaziz Mohsen, Mamdouh, Wael, Amin, Abeer M., El-Bary, Ahmed Abd
Format: Article
Language:English
Subjects:
Biodistribution
Doxorubicin
Radioiodination
Silver nanoparticle composite
Tumor localization
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Summary:This study aimed at improving the radioiodination of doxorubicin (DOX) and its localization in cancer cell for theranostic purposes. To achieve this goal, a composite of DOX with polyvinyl pyrrolidone (PVP) and silver nanoparticles (AgNPs) was prepared. Both DOX and (DOX/PVP/AgNPs) were radiolabelled with iodine-125 [125I] and optimized using iodogen as a preferable oxidizing agent. The maximum obtained radiochemical yields for both systems were 79.9% and 96.6%, respectively. Interestingly, the biodistribution study revealed that [125I]DOX/PVP/AgNPs had an effective localization on tumors. Moreover, Target/control target (T/CT) ratio of [125I] DOX/PVP/AgNPs showed the highest value of 9.1 at 1 h post injection, suggesting that [125I]DOX/PVP/AgNPs has a great potential as a proposed tumor targeting agent. [Display omitted] •Radioiodination of DOX and DOX/PVP/Ag NPs was done using Iodogen as oxidizer.•The tumor uptake of 125I-DOX and 125I-DOX/PVP/Ag NPs in tumor bearing mice were studied.•The data demonstrated the high localization of DOX/PVP/Ag NPs in the tumor site (37.5 ± 0.4%) after 1 h p.i.•Iodogen improved the radioiodinated yield, the stability of 125I-DOX/PVP/Ag NPs and the biodistribution pattern of it.•125I-DOX/PVP/AgNPs was suggested as a proposed tumor targeting agent.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2022.110288