Socioeconomic disparity in cardiovascular disease: Possible biological pathways based on a proteomic approach

Large social disparities in the occurrence of cardiovascular disease (CVD) have been documented but the underlying biological mechanisms are largely unknown. We investigated a panel of biomarkers linked to CVD to improve our understanding and quantify the biological pathways in socioeconomic dispari...

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Bibliographic Details
Published in:Atherosclerosis 2022-07, Vol.352, p.62-68
Main Authors: Shafi, Bilal Hasan, Bøttcher, Morten, Ejupi, Ali, Jensen, Gorm, Osler, Merete, Lange, Theis, Prescott, Eva
Format: Article
Language:English
Subjects:
Biological pathways
Biomarkers
Cardiovascular disease
Mediation analysis
Proteomics
Socioeconomic position
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Summary:Large social disparities in the occurrence of cardiovascular disease (CVD) have been documented but the underlying biological mechanisms are largely unknown. We investigated a panel of biomarkers linked to CVD to improve our understanding and quantify the biological pathways in socioeconomic disparity in CVD and their mediation through behavioural and biological risk factors. We included 1142 participants from the Copenhagen City Heart Study aged 55–64 years. Socioeconomic position (SEP) was defined by the length of education and household income. Blood samples were analysed for 184 biomarkers (Olink). Pearson's correlation analysis and linear regression with multivariate adjustment for CVD risk factors were performed. The median length of education was 10 (IQR 7–11) years and associated with age, sex, BMI, smoking, blood pressure, physical activity and income. 48 biomarkers were significantly correlated (p 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2022.05.020