Impact of dysphagia and its severity on long‐term survival and swallowing function outcomes in patients with idiopathic inflammatory myopathies other than inclusion body myositis

Objective To investigate the impact of dysphagia on long‐term survival and swallowing function outcomes in patients with idiopathic inflammatory myopathy other than inclusion body myositis. Methods We retrospectively evaluated consecutive patients with idiopathic inflammatory myopathy other than inc...

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Bibliographic Details
Published in:International journal of rheumatic diseases 2022-08, Vol.25 (8), p.897-909
Main Authors: Ohmura, Shin‐ichiro, Tamechika, Shin‐ya, Miyamoto, Toshiaki, Kunieda, Kenjiro, Naniwa, Taio
Format: Article
Language:English
Subjects:
Comorbidity
deglutition disorders
Dysphagia
Food intake
idiopathic inflammatory myopathy
Inflammation
Inflammatory diseases
Medical prognosis
Multivariate analysis
Musculoskeletal diseases
Myopathy
Myositis
outcome assessment
Survival
Swallowing
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Summary:Objective To investigate the impact of dysphagia on long‐term survival and swallowing function outcomes in patients with idiopathic inflammatory myopathy other than inclusion body myositis. Methods We retrospectively evaluated consecutive patients with idiopathic inflammatory myopathy other than inclusion body myositis to investigate the impact of dysphagia and its severity assessed using the Food Intake LEVEL Scale on survival and swallowing function outcomes. Time‐to‐event analyses were used, including Kaplan‐Meier curves with log‐rank (trend) test, cumulative incidence with Gray’s test, and Cox proportional hazards models. Results Of the 254 patients, 26 were dysphagic, including eight severe (Food Intake LEVEL Scale [FILS] score 2, 3) and six most severe (FILS score 1) cases; 210 were non‐dysphagic, and 18 were indeterminate cases. During the 5 years after myositis diagnosis, 15 (57.7%) dysphagic and 31 (14.8%) non‐dysphagic patients died, and dysphagic patients had significantly shorter survival. However, multivariate analysis showed that shorter survival was significantly associated with baseline age‐adjusted Charlson Comorbidity Index (hazard ratio [HR] 1.57, 95% confidence interval [CI] 1.36‐1.82]), but not with dysphagia (HR 1.46, 95% CI 0.69‐3.10). Dysphagia severity was significantly associated with delayed recovery of dysphagia. In 20 non‐severe or severe dysphagic cases, 19 restored swallowing function within 1 year. The most severe cases had a significantly higher cumulative probability of death before recovery from dysphagia than severe cases. Conclusion The poor survival of dysphagic myositis patients was largely confounded by advanced age and comorbid malignancies. However, patients with the most severe dysphagia had a significantly worse swallowing function and survival prognosis than those with milder dysphagia.
ISSN:1756-1841
1756-185X
DOI:10.1111/1756-185X.14365