Electroencephalogram in low-risk term newborns predicts neurodevelopmental metrics at age two years

•Spectral metric of scalp and source EEG of term low-risk newborns was associated with neurodevelopmental scores at 2 years of age.•Source-level analysis identified the brain regions associated with the developmental metrics.•Newborn EEG may identify even low-risk infants who will deviate from the t...

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Published in:Clinical neurophysiology 2022-08, Vol.140, p.21-28
Main Authors: Chirumamilla, Venkata C., Hitchings, Laura, Mulkey, Sarah B., Anwar, Tayyba, Baker, Robin, Larry Maxwell, G., De Asis-Cruz, Josepheen, Kapse, Kushal, Limperopoulos, Catherine, du Plessis, Adre, Govindan, R.B.
Format: Article
Language:English
Subjects:
Automated anatomical labeling atlas
Developmental assessment
Linearly constrained minimum variance beamformer
Low-risk term newborns
Source reconstruction
Spectral analysis
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Summary:•Spectral metric of scalp and source EEG of term low-risk newborns was associated with neurodevelopmental scores at 2 years of age.•Source-level analysis identified the brain regions associated with the developmental metrics.•Newborn EEG may identify even low-risk infants who will deviate from the typical developmental trajectory in future. To determine whether neurodevelopmental biomarkers at 2 years of age are already present in the newborns’ EEG at birth. Low-risk term newborns were enrolled and studied utilizing EEG prior to discharge from the birth hospital. A 14-channel EEG montage (scalp-level) and source signals were calculated using the EEG. Their spectral power was calculated for each of the five frequency bands. Cognitive, language and motor skills were assessed using the Bayley Scales of Infant Development-III at age 2 years. The relationship between the spectral power in each frequency band and neurodevelopmental scores were quantified using the Spearman’s r. The role of gender, gestational age (GA) and delivery mode, if found significant (P 
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2022.05.010