Validation of the patient State Index for monitoring sedation state in critically ill patients: a prospective observational study

Purpose The Patient State Index (PSI) is a newly introduced electroencephalogram-based tool for objective and continuous monitoring of sedation levels of patients under general anesthesia. This study investigated the potential correlation between the PSI and the Richmond Agitation‒Sedation Scale (RA...

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Bibliographic Details
Published in:Journal of clinical monitoring and computing 2023-02, Vol.37 (1), p.147-154
Main Authors: Idei, Masafumi, Seino, Yusuke, Sato, Nobuo, Yoshida, Takuya, Saishu, Yumi, Fukui, Kimiya, Iwabuchi, Masahiro, Ishikawa, Junya, Ota, Kei, Kamei, Daigo, Nakagawa, Masashi, Nomura, Takeshi
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia, General
Anesthesiology
Chi-square test
Correlation coefficients
Critical Care
Critical Care Medicine
Critical Illness
Health Sciences
Humans
Hypnotics and Sedatives
Intensive
Intensive Care Units
Medical personnel
Medicine
Medicine & Public Health
Monitoring
Observational studies
Original Research
Pain
Patients
Respiration, Artificial
Sensitivity
Statistics for Life Sciences
Telemedicine
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Summary:Purpose The Patient State Index (PSI) is a newly introduced electroencephalogram-based tool for objective and continuous monitoring of sedation levels of patients under general anesthesia. This study investigated the potential correlation between the PSI and the Richmond Agitation‒Sedation Scale (RASS) score in intensive care unit (ICU) patients and established the utility of the PSI in assessing sedation levels. Methods In this prospective observational study, PSI values were continuously monitored via SedLine® (Masimo, Irvine, CA, USA); the RASS score was recorded every 2 h for patients on mechanical ventilation. Physicians and nurses were blinded to the PSI values. Overall, 382 PSI and RASS score sets were recorded for 50 patients. Results The PSI score correlated positively with RASS scores, and Spearman’s rank correlation coefficient between the PSI and RASS was 0.79 (95% confidence interval [CI]: 0.75‒0.83). The PSI showed statistically significant difference among the RASS scores (Kruskal‒Wallis chi-square test: 242, df = 6, P 
ISSN:1387-1307
1573-2614
DOI:10.1007/s10877-022-00871-9