Structurally diverse abietane-type Diterpenoids from the aerial parts of Gaultheria leucocarpa var. yunnanensis

Seven undescribed abietane-type diterpenoids, gauleucins A−G, and 11 known ones were isolated from an EtOH extract of the aerial parts of Gaultheria leucocarpa var. yunnanensis. These isolates could be classified into four subtypes: abietanes, 16-nor-abietanes, 16,18-di-nor-abietanes, and 3,4-seco-1...

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Published in:Phytochemistry (Oxford) 2022-09, Vol.201, p.113255-113255, Article 113255
Main Authors: Hu, Ya-Jie, Lan, Qian, Su, Bao-Jun, Chen, Zhen-Feng, Liang, Dong
Format: Article
Language:English
Subjects:
Abietane-type diterpenoids
Anti-inflammatory
Ericaceae
Gaultheria leucocarpa var. Yunnanensis
α-Glucosidase inhibitory activity
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Summary:Seven undescribed abietane-type diterpenoids, gauleucins A−G, and 11 known ones were isolated from an EtOH extract of the aerial parts of Gaultheria leucocarpa var. yunnanensis. These isolates could be classified into four subtypes: abietanes, 16-nor-abietanes, 16,18-di-nor-abietanes, and 3,4-seco-16-nor-abietane. Their structures were established by extensive spectroscopic analysis, and the absolute configurations of an undescribed and two known diterpenoids were determined by single-crystal X-ray diffraction data. Four compounds showed moderate inhibitory effects against the LPS-induced production of nitric oxide in BV-2 microglial cells. In an α-glucosidase inhibitory assay, gauleucin E and margoclin displayed inhibitory activities with IC50 values of 319.3 and 327.9 μM, respectively, while the IC50 value of the positive control (acarbose) was 387.8 μM. Seven undescribed abietane-type diterpenoids, gauleucins A−G, together with 11 known ones were isolated from Gaultheria leucocarpa var. yunnanensis. All the isolated diterpenoids were evaluated for their anti-inflammatory and α-glucosidase inhibitory activities. [Display omitted] •Seven undescribed abietane-type diterpenoids were isolated from Gaultheria leucocarpa var. yunnanensis.•The absolute configurations of all the isolates were established by X-ray diffraction (Cu Kα radiation) and ECD data.•Four compounds exhibited anti-inflammatory activity, and two abietanes displayed α-glucosidase inhibitory activity.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2022.113255