Electroporation, electrochemotherapy and electro-assisted drug delivery in cancer. A state-of-the-art review

This review focuses on electrochemotherapy that consists in the delivery of anti-cancer drugs using high-voltage electrical pulses. Technical issues, choice of drugs, and protocol of drug delivery are still under investigation and no consensus has been achieved yet. The different aspects of electroc...

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Bibliographic Details
Published in:Biophysical chemistry 2022-07, Vol.286, p.106819-106819, Article 106819
Main Authors: Tsoneva, Iana, Semkova, Severina, Bakalova, Rumiana, Zhelev, Zhivko, Nuss, Philippe, Staneva, Galya, Nikolova, Biliana
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Drug Delivery Systems
Electro-assisted drug delivery
Electrochemotherapy
Electrochemotherapy - methods
Electroporation
Electroporation - methods
Humans
Multidrug resistance
Nanoparticles
Neoplasms - pathology
Pharmaceutical Preparations
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Summary:This review focuses on electrochemotherapy that consists in the delivery of anti-cancer drugs using high-voltage electrical pulses. Technical issues, choice of drugs, and protocol of drug delivery are still under investigation and no consensus has been achieved yet. The different aspects of electrochemotherapy are discussed in the present paper. It includes interrogations about the choice of the preferred anti-cancer drug and dose to be delivered on the solid tumors. Another promising area is related to the electro-assisted release of nanoparticles (quantum dots) in xenografted solid tumors. Molecular mechanisms of enhanced drug delivery are discussed in terms of high cholesterol level and large fraction of lipid rafts in cancer cells. Electrochemotherapy is a paradigmatic example of cooperation between physicists, biophysicists, chemists, technicians, manufacturers, biologists, clinicians, and patients to improve a very promising treatment delivery in line with the conception of personalized medicine. [Display omitted] •Electrochemotherapy: delivery of anti-cancer drugs using high-voltage electrical pulses.•Choice and dose of drugs, protocols of drug delivery.•Electro-assisted release of nanoparticles (quantum dots) in xenografted solid tumors.•Molecular mechanisms of passive drug delivery and electro-assisted enhanced one.
ISSN:0301-4622
1873-4200
DOI:10.1016/j.bpc.2022.106819