Valve-Sparing Aortic Root Replacement in a Patient With an FLNA Variant

We report a case of a 38-year-old female with an FLNA variant who underwent valve-sparing aortic root replacement. FLNA encodes Filamin A, an actin-binding protein. Our patient had aortic root dilation due to this variant. Aortic root repair was conducted using the David procedure, with modification...

Full description

Saved in:
Bibliographic Details
Published in:World journal for pediatric & congenital heart surgery 2022-11, Vol.13 (6), p.805-807
Main Authors: Lobbestael, Adam J., Bupp, Caleb P., Haw, Marcus P.
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report a case of a 38-year-old female with an FLNA variant who underwent valve-sparing aortic root replacement. FLNA encodes Filamin A, an actin-binding protein. Our patient had aortic root dilation due to this variant. Aortic root repair was conducted using the David procedure, with modifications to account for tissue fragility associated with this genetic condition. This case demonstrates the value of patient-specific genetic information for the timing of surgery and operative course planning.
ISSN:2150-1351
2150-136X
DOI:10.1177/21501351221099272