Testosterone kinetics on hypogonadal men under clomiphene

Objective To evaluate total testosterone (TT) kinetics and its predictors 6 months after the discontinuation of clomiphene citrate (CC) in patients with hypogonadism. Materials and methods Consecutive patients with normal testicles and male hypogonadism defined by TT  300 ng/dl was achieved by 69 (9...

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Bibliographic Details
Published in:International urology and nephrology 2022-08, Vol.54 (8), p.1807-1813
Main Authors: Silva, Élcio Dias, da Silva, Maurício Moreira, Moretti, Tomas B. C., Andrade, Danilo L., Avilez, Natália Dalsenter, Reis, Leonardo O.
Format: Article
Language:English
Subjects:
Clomiphene
Hypogonadism
Medicine
Medicine & Public Health
Nephrology
Patients
Testosterone
Urology
Urology - Original Paper
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Summary:Objective To evaluate total testosterone (TT) kinetics and its predictors 6 months after the discontinuation of clomiphene citrate (CC) in patients with hypogonadism. Materials and methods Consecutive patients with normal testicles and male hypogonadism defined by TT  300 ng/dl was achieved by 69 (92%), 450–600 ng/dl by 32 (42.6%), and > 600 ng/dl by 27 (36.0%). 18 subjects (24%) maintained asymptomatic and TT levels over 300 ng/dl at T 2 . Age negatively related to testosterone response and T 1 response > 810 ng/dl predicts a median gain of 166.5 ng/dl at 6 months of CC discontinuation. Conclusions CC is a compelling option to treat male hypogonadism, although a chronic treatment is needed in most patients. About one in every four patients respond to a CC short trial to "reboot" the physiology. Further understanding of TT kinetics in these patients in the long term is warranted.
ISSN:1573-2584
0301-1623
1573-2584
DOI:10.1007/s11255-022-03230-4