Photoinduced Three-Component Difluoroalkylation of Quinoxalinones with Alkenes via Difluoroiodane(III) Reagents

An environmentally friendly strategy for the photocatalyzed three-component reaction between quinoxalinones, alkenes, and hypervalent iodine­(III) reagents is disclosed. The new designed difluoroiodane­(III) reagent shows excellent reactivity, providing a wide range of difluoroalkyl-substituted quin...

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Bibliographic Details
Published in:Organic letters 2022-05, Vol.24 (19), p.3576-3581
Main Authors: Zhou, Ningning, Liu, Ruiyue, Zhang, Chunmeng, Wang, Kun, Feng, Jiaxu, Zhao, Xia, Lu, Kui
Format: Article
Language:English
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Summary:An environmentally friendly strategy for the photocatalyzed three-component reaction between quinoxalinones, alkenes, and hypervalent iodine­(III) reagents is disclosed. The new designed difluoroiodane­(III) reagent shows excellent reactivity, providing a wide range of difluoroalkyl-substituted quinoxaline-2­(1H)-ones in moderate to excellent yields under mild conditions. Experimental studies demonstrated that a difluoroalkyl radical intermediate was involved in this reaction.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c01358