Fast track to personalized TCR T cell therapies

In this issue of Cancer Cell, Hanada et al. leverage single-cell multi-omics of lung cancer resident lymphocytes to identify phenotypic and transcriptomic signatures differentially expressed by neoantigen-reactive clonotypes. These findings could substantially expedite the selection of neoantigen-sp...

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Bibliographic Details
Published in:Cancer cell 2022-05, Vol.40 (5), p.447-449
Main Authors: Levy, Pierre L., Gros, Alena
Format: Article
Language:English
Subjects:
Antigens, Neoplasm
Humans
Lymphocytes
Receptors, Antigen, T-Cell - genetics
T-Lymphocytes
Transcriptome
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Summary:In this issue of Cancer Cell, Hanada et al. leverage single-cell multi-omics of lung cancer resident lymphocytes to identify phenotypic and transcriptomic signatures differentially expressed by neoantigen-reactive clonotypes. These findings could substantially expedite the selection of neoantigen-specific T cell receptors (TCRs) for individualized T cell therapies. In this issue of Cancer Cell, Hanada et al. leverage single-cell multi-omics of lung cancer resident lymphocytes to identify phenotypic and transcriptomic signatures differentially expressed by neoantigen-reactive clonotypes. These findings could substantially expedite the selection of neoantigen-specific T cell receptors (TCRs) for individualized T cell therapies.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccell.2022.04.013