Tissue engineered drug delivery vehicles: Methods to monitor and regulate the release behavior

Tissue engineering is a rapidly evolving, multidisciplinary field that aims at generating or regenerating 3D functional tissues for in vitro disease modeling and drug screening applications or for in vivo therapies. A variety of advanced biological and engineering methods are increasingly being used...

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Bibliographic Details
Published in:Journal of controlled release 2022-09, Vol.349, p.143-155
Main Authors: Gil, Carmen J., Li, Lan, Hwang, Boeun, Cadena, Melissa, Theus, Andrea S., Finamore, Tyler A., Bauser-Heaton, Holly, Mahmoudi, Morteza, Roeder, Ryan K., Serpooshan, Vahid
Format: Article
Language:English
Subjects:
Controlled release
Drug delivery
Microparticles
Molecular contrast agents
Nanoparticles
Noninvasive imaging
Quantum dots
Tissue engineering scaffolds
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Summary:Tissue engineering is a rapidly evolving, multidisciplinary field that aims at generating or regenerating 3D functional tissues for in vitro disease modeling and drug screening applications or for in vivo therapies. A variety of advanced biological and engineering methods are increasingly being used to further enhance and customize the functionality of tissue engineered scaffolds. To this end, tunable drug delivery and release mechanisms are incorporated into tissue engineering modalities to promote different therapeutic processes, thus, addressing challenges faced in the clinical applications. In this review, we elaborate the mechanisms and recent developments in different drug delivery vehicles, including the quantum dots, nano/micro particles, and molecular agents. Different loading strategies to incorporate the therapeutic reagents into the scaffolding structures are explored. Further, we discuss the main mechanisms to tune and monitor/quantify the release kinetics of embedded drugs from engineered scaffolds. We also survey the current trend of drug delivery using stimuli driven biopolymer scaffolds to enable precise spatiotemporal control of the release behavior. Recent advancements, challenges facing current scaffold-based drug delivery approaches, and areas of future research are discussed. [Display omitted]
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2022.04.044