The anterior thalamic nuclei: core components of a tripartite episodic memory system

Standard models of episodic memory focus on hippocampal-parahippocampal interactions, with the neocortex supplying sensory information and providing a final repository of mnemonic representations. However, recent advances have shown that other regions make distinct and equally critical contributions...

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Bibliographic Details
Published in:Nature reviews. Neuroscience 2022-08, Vol.23 (8), p.505-516
Main Authors: Aggleton, John P, O'Mara, Shane M
Format: Article
Language:English
Subjects:
Cognitive ability
Cortex (somatosensory)
Cortex (temporal)
Hippocampus
Memory
Neocortex
Parahippocampal gyrus
Temporal lobe
Thalamic nuclei
Thalamus
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Summary:Standard models of episodic memory focus on hippocampal-parahippocampal interactions, with the neocortex supplying sensory information and providing a final repository of mnemonic representations. However, recent advances have shown that other regions make distinct and equally critical contributions to memory. In particular, there is growing evidence that the anterior thalamic nuclei have a number of key cognitive functions that support episodic memory. In this article, we describe these findings and argue for a core, tripartite memory system, comprising a 'temporal lobe' stream (centred on the hippocampus) and a 'medial diencephalic' stream (centred on the anterior thalamic nuclei) that together act on shared cortical areas. We demonstrate how these distributed brain regions form complementary and necessary partnerships in episodic memory formation.
ISSN:1471-003X
1471-0048
1469-3178
DOI:10.1038/s41583-022-00591-8