Comparison of left ventricular subclinical systolic dysfunction between hemodialysis patients and renal transplant recipients using real time three‐dimensional echocardiography

Aims The relationship between chronic kidney disease and development of heart failure is a well‐known clinical entity. Systolic dyssynchrony index (SDI_16) is a new diagnostic tool for detection of subclinical left ventricular (LV) systolic dysfunction by using three‐dimensional echocardiography (3D...

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Bibliographic Details
Published in:Echocardiography (Mount Kisco, N.Y.) N.Y.), 2022-05, Vol.39 (5), p.708-716
Main Authors: Ekmekci, Cenk, Cabuk, Ali Kemal
Format: Article
Language:English
Subjects:
hemodialysis
left ventricle
renal transplant
systolic dyssynchrony index
three‐dimensional echocardiography
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Summary:Aims The relationship between chronic kidney disease and development of heart failure is a well‐known clinical entity. Systolic dyssynchrony index (SDI_16) is a new diagnostic tool for detection of subclinical left ventricular (LV) systolic dysfunction by using three‐dimensional echocardiography (3DE). We aimed to investigate this parameter in patients with end‐stage renal disease who were receiving hemodialysis and patients with renal transplant compared to healthy control subjects. Material and Methods Forty‐five hemodialysis patients, 45 patients with renal transplant and 45 age‐sex matched healthy control subjects included in the study. All participants were evaluated with 3DE in the interdialytic phase for measurement of LV volumes, ejection fraction and SDI_16 parameter. Results Both LV diastolic and systolic volumes were significantly higher in hemodialysis group compared to renal transplant group and healthy controls, but this finding did not translate to a statistically significant difference for LVEF measurements between groups (58.71 ± 3.53 vs. 57.17 ± 2.97 vs. 59.23 ± 3.26, p = .16 for renal transplant and hemodialysis and healthy control groups, respectively). Mean value of SDI_16 parameters was significantly higher in hemodialysis group compared to renal transplant group (7.93 ± 2.50 vs. 3.72 ± 1.71, p < .001) and healthy controls (7.93 ± 2.50 vs. 3.00 ± .99, p < .001); whereas, it was similar between renal transplant group and control subjects (3.72 ± 1.71 vs. 3.00 ± .99, p = .10). Conclusion SDI_16 was significantly higher in hemodialysis patients compared to patients with renal transplant and healthy controls.
ISSN:0742-2822
1540-8175
DOI:10.1111/echo.15352