Effect of different anesthetic dose of pentobarbital on respiratory activity in rabbits

Anesthetics inhibit the respiratory muscles and even cause upper airway to collapse. Diaphragm electromyography (EMGdi) and airflow signals are usually extracted to assess the degree of respiration inhibition by anesthetics. However, the ECG interference in EMGdi affects the accuracy of its time dom...

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Bibliographic Details
Published in:Computers in biology and medicine 2022-06, Vol.145, p.105501-105501, Article 105501
Main Authors: Gu, Xiaoyu, Zhao, Xuelin, Mao, Zhihao, Shi, Yan, Xu, Meng, Cai, Maolin, Xie, Fei
Format: Article
Language:English
Subjects:
Abdomen
Air flow
Airflow
Airway management
Algorithms
Anesthesia
Anesthetics
Anesthetics - pharmacology
Animals
Centroids
Data acquisition systems
Decomposition
Diaphragm
Diaphragm (Anatomy)
Diaphragm - physiology
EKG
Electrocardiography
Electrodes
Electromyography
Electromyography - methods
Entropy
Esophagus
Fatigue
Information retrieval
Interference
Intubation
Laboratory animals
Mathematical analysis
Mechanical ventilation
Muscles
Noise
Noise reduction
Pentobarbital
Pentobarbital - pharmacology
Pentobarbital anesthesia
Power spectrum
Quantification of diaphragm electromyography
Rabbits
Respiratory Rate
Software
Spectrum analysis
Stationary wavelet transform
Wavelet transforms
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Summary:Anesthetics inhibit the respiratory muscles and even cause upper airway to collapse. Diaphragm electromyography (EMGdi) and airflow signals are usually extracted to assess the degree of respiration inhibition by anesthetics. However, the ECG interference in EMGdi affects the accuracy of its time domain and frequency domain information extraction. We studied the changes in EMGdi (left EMGdi and right EMGdi) and airflow characteristics under two pentobarbital anesthetic doses. First, we filtered out the ECG in EMGdi based on the combination of stationary wavelet transform and the positioning of ECG to obtain EMGdi without ECG interference (EMGdip). The effectiveness of filtering algorithm was verified by calculating the power spectrum before and after noise reduction. Second, root mean square (RMS), average rectified value (ARV), and fixed sample entropy (fSampEn) were used to quantify EMGdi (left EMGdi, left EMGdip and right EMGdi). Median frequency (MF) and centroid frequency (fc) of EMGdi were calculated. Tidal volume, respiratory cycle duration and peak airflow were calculated from airflow. Finally, the average and standard deviation of these parameters for all rabbits (n = 10) were compared and analyzed under two anesthesia states. Our results indicate that anesthesia induced by an increase in pentobarbital dose leads to decrease in ventilation and EMGdi amplitude. There was no significant change in diaphragm power spectrum (MF and fc) with the increase of anesthesia dose. •Pentobarbital dose significantly inhibits breathing.•Removal of electrocardiogram interference in diaphragm electromyography by stationary wavelet transform.•Quantification of diaphragm electromyography.•Robustness of fixed sample entropy to electrocardiogram interference.•Assessing diaphragmatic fatigue using power spectra.
ISSN:0010-4825
1879-0534
DOI:10.1016/j.compbiomed.2022.105501