B lymphocytes subpopulations are associated with cardiac remodeling in elderly patients with advanced chronic kidney disease

Chronic Kidney Disease (CKD) is independently associated with increased cardiovascular disease (CVD) risk. The aim of this study was to investigate the potential roles of B lymphocyte populations with cardiac remodeling in elderly patients with advanced CKD. We designed a retrospective study in a co...

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Bibliographic Details
Published in:	Experimental gerontology 2022-06, Vol.163, p.111805-111805, Article 111805
Main Authors:	Lin, Jieshan, Tang, Bin, He, Ganyuan, Feng, Zhanwu, Hao, Wenke, Hu, Wenxue
Format:	Article
Language:	eng
Subjects:	Aged B cells B-Lymphocyte Subsets Biomarkers Cardiac remodeling Chronic kidney disease Echocardiography Elderly Female Humans Male Natriuretic Peptide, Brain Renal Insufficiency, Chronic - complications Retrospective Studies Ventricular Remodeling
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Summary:	Chronic Kidney Disease (CKD) is independently associated with increased cardiovascular disease (CVD) risk. The aim of this study was to investigate the potential roles of B lymphocyte populations with cardiac remodeling in elderly patients with advanced CKD. We designed a retrospective study in a cohort of 167 patients (84 advanced CKD patients with stage 4–5 and 83 non-CKD controls). B cell subsets: CD19(+)CD5(+) and CD19(+)CD5(−) B cells were identified by flow cytometry. Correlation of B cells subsets with cardiac remodeling and clinical data in elderly CKD patients were analyzed. In this study, we found that the prevalence of hypertension was more common in CKD patients than in the control subjects (P
ISSN:	0531-5565 1873-6815