Vascular endothelial growth factor (VEGF) and interleukin-1 receptor antagonist (IL-1Ra) as promising biomarkers for distinguishing active from latent tuberculosis in children and adolescents

Since distinguishing pulmonary (PTB) from latent tuberculosis (LTBI) in pediatric patients remains a challenge, we aimed to investigate the efficacy of immune mediators in diagnosing PTB and LTBI in this population. In this cross-sectional study performed with children and adolescents, serum levels...

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Published in:Tuberculosis (Edinburgh, Scotland) Scotland), 2022-05, Vol.134, p.102205-102205, Article 102205
Main Authors: Martins, Camila de Paula, Carvalho, Fabiana Rabe, Faustino, Renan, Medeiros, Thalia, Rosário, Natalia Fonseca do, Schmidt, Christiane Mello, Barbosa, Ana Paula, Quintanilha dos Santos, Ana Paula, Pluvier Duarte Costa, Caio, Kegler dos Santos, Hugo Henrique, Yuriko Yaginuma, Karina, Costa da Silva, Elisangela, Lineu Kritski, Afranio, Couto Sant’Anna, Clemax, Araújo Cardoso, Claudete Aparecida, Silva, Andrea Alice
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Biomarkers
Child
Child, Preschool
Children
Cross-Sectional Studies
Growth factors
Humans
IL-1Ra
Inflammatory mediators
Interleukin 1
Interleukin 1 receptor antagonist
Interleukin 1 Receptor Antagonist Protein
Interleukin 1 receptors
Interleukin 6
Interleukins
Interstitial collagenase
Latent Tuberculosis
Matrix metalloproteinase
Mycobacterium tuberculosis
Patients
Pediatrics
Population studies
Principal components analysis
Procalcitonin
Receptors, Interleukin-1
Serum levels
Teenagers
Tuberculosis
Tumor necrosis factor-α
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
VEGF
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Summary:Since distinguishing pulmonary (PTB) from latent tuberculosis (LTBI) in pediatric patients remains a challenge, we aimed to investigate the efficacy of immune mediators in diagnosing PTB and LTBI in this population. In this cross-sectional study performed with children and adolescents, serum levels of 20 biomarkers were assessed and data were analyzed according to age groups. We included 65 participants (PTB, n = 28 and LTBI, n = 37). Overall, levels of TNF-α, IL-1Ra, IL-6, IL-17A, VEGF, MMP-1, and procalcitonin were significantly higher (P 
ISSN:1472-9792
1873-281X
DOI:10.1016/j.tube.2022.102205