Association Between Serum Selenium Concentration and OPG/RANKL/RANK Axis in Patients with Arterial Hypertension

The aim of the study was to determine the relationship between the serum selenium concentration (Se–S) and the blood concentrations of osteoprotegerin (OPG), receptor activator of nuclear factor kappa-Β ligand (RANKL) and the OPG/RANKL ratio in patients with arterial hypertension. The study group co...

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Published in:Cardiovascular toxicology 2022-07, Vol.22 (7), p.620-630
Main Authors: Czerwińska, Karolina, Poręba, Małgorzata, Prokopowicz, Adam, Januszewska, Lidia, Jaremków, Aleksandra, Markiewicz-Górka, Iwona, Martynowicz, Helena, Mazur, Grzegorz, Poręba, Rafał, Pawlas, Krystyna, Gać, Paweł
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
Biomedical and Life Sciences
Biomedical materials
Biomedicine
Blood pressure
Body mass
Body mass index
Body size
Bone turnover
Calcification
Cardiology
Care and treatment
Correlation analysis
Diuretics
Humans
Hypertension
Hypertension - diagnosis
Hypertension - drug therapy
Medical research
Medicine, Experimental
Metabolism
Middle Aged
NF-kappa B
Osteoprotegerin
Parameters
Pharmacology/Toxicology
Physiological aspects
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B - metabolism
Regression analysis
Risk analysis
Risk factors
Selenium
Subgroups
TRANCE protein
Type 2 diabetes
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Summary:The aim of the study was to determine the relationship between the serum selenium concentration (Se–S) and the blood concentrations of osteoprotegerin (OPG), receptor activator of nuclear factor kappa-Β ligand (RANKL) and the OPG/RANKL ratio in patients with arterial hypertension. The study group comprised 138 patients with arterial hypertension (age: 56.04 ± 11.59 years). Se–S was determined in all the subjects. Based on the Se–S, the following subgroups were distinguished: a subgroup of patients with a lower Se–S ("low-Se", Se–S 
ISSN:1530-7905
1559-0259
DOI:10.1007/s12012-022-09741-x