Boron Lewis Acid Catalyzed Intermolecular trans-Hydroarylation of Ynamides with Hydroxyarenes

An atom-economic protocol for the efficient and highly chemo- and stereoselective trans-hydroarylation of ynamides with hydroxyarenes catalyzed by B­(C6F5)3 has been developed. Use of readily available starting materials, low catalyst loading, mild reaction conditions, a broad substrate scope, ease...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2022-04, Vol.24 (14), p.2619-2624
Main Authors: Xiao, Yuanjiu, Tang, Lei, Xu, Tong-Tong, Feng, Jian-Jun
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An atom-economic protocol for the efficient and highly chemo- and stereoselective trans-hydroarylation of ynamides with hydroxyarenes catalyzed by B­(C6F5)3 has been developed. Use of readily available starting materials, low catalyst loading, mild reaction conditions, a broad substrate scope, ease of scale-up, and versatile functionalizations of the enamide products make this approach very practical and attractive.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c00574